NIAID Transplant Programs
NIAID supports research that focuses on understanding the role the immune system plays in the success or failure of transplanted cells, tissues, and organs. Researchers are studying ways to selectively control or eliminate unwanted immune responses with the ultimate goal of enhancing long-term transplant survival.
Clinical Trials in Organ Transplantation in Children and Adults (CTOT-CA)
Learn MoreCTOT-CA will conduct clinical research addressing the immunologic and infectious barriers to long-term success of transplantation in interventional trials (Phase I, II, or III) or observational clinical studies in organ transplantation (heart, kidney, lung, and liver). The goals of this research are to further our understanding of and ultimately reduce immune- and infection-mediated morbidity and mortality associated with organ transplantation.
Immune Tolerance Network (ITN)
Learn MoreThe ITN conducts clinical trials, mechanistic studies, and assay development in transplantation with a focus on tolerogenic approaches to improve the long-term outcomes of allotransplantation. ITN Transplantation research priorities include innovative tolerogenic approaches to improve long-term graft survival and decrease the adverse immunologic consequences of allotransplantation and pharmacologic immunosuppression.
Investigator Initiated Clinical Trials (IICT)
Learn MoreNIAID supports investigator-initiated clinical trials using the R01 or U01 funding mechanism. The IICT process was created to support a limited number of IICTs outside the existing clinical trial networks. Investigators can consult with NIAID in advance of grant submission to ensure research goals align with NIAID's mission.
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